AUTISM OVERVIEW
Understanding autism spectrum disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by differences in communication, social interaction, behavior, sensory processing, and emotional regulation. The term spectrum reflects the wide variability in how autism presents—from mild to severe, stable to regressive, and from primarily behavioral to strongly medical in nature.
Autism is not a single disease, but a complex condition with multiple contributing biological pathways.
PANS/PANDAS (IN SIMPLE TERMS)
01
The Official Medical View (Current Consensus)
According to mainstream medical guidelines, autism is considered a neurodevelopmental disorder with:
Early onset (typically before age 3)
A strong genetic component
Involvement of altered brain connectivity and development
PANDAS is the form most strongly linked to strep, but many children also have other infections involved.
Genetics and Risk Factors
The official view recognizes:
Reviews the child’s medical and developmental history
Analyzes available laboratory data
Correlates laboratory findings with clinical presentation and symptom dynamics
However, no single gene explains most autism cases, and genetics alone cannot account for regression, symptom changes, or treatment response
Current Standard of Care
Mainstream care focuses on:
Behavioral and educational interventions (e.g., ABA, speech therapy)
Supportive services
Symptom management
Medical causes are often considered secondary or unrelated to core autism features
A Science-Based Biological Overview (Our Perspective)
02
Autism as a Disorder of Dysregulated Systems
From a biological and clinical standpoint, autism can be understood as a condition of chronic dysregulation, involving:
The developing brain
The immune system
The gut microbiome
Metabolic and neuroendocrine systems
In many children, autism is not “just genetics.” It often involves ongoing biology that can be addressed.
The Role of Congenital and Early Postnatal Infections
03
Growing clinical and scientific evidence indicates that autism often begins with congenital or early postnatal infections, particularly:
Neurotropic pathogens (affecting the brain)
Immunomodulatory pathogens (altering immune development)
These infections can:
Disrupt fetal and early brain development
Alter immune system programming
Prime the body for chronic inflammatory responses
In many children, autism is not “just genetics.” It often involves ongoing biology that can be addressed.
Immune Dysregulation and Infection Persistence
04
When early immune programming is disrupted:
The immune system may fail to clear later infections effectively
Latent and chronic pathogens (viral, bacterial, fungal) can persist
Biofilm-forming microbes may develop in the gut and other tissues
Rather than isolated infections, many children develop a cumulative infectious burden.
PANDAS is the form most strongly linked to strep, but many children also have other infections involved.
Gut Dysbiosis and Systemic Inflammation
05
Persistent infections contribute to:
Gut microbiome imbalance (dysbiosis)
Intestinal barrier dysfunction
Immune activation originating in the gut
As dysbiosis worsens:
Systemic inflammation increases
Immune signals affect the brain
Metabolic and detoxification pathways become strained
PANDAS is the form most strongly linked to strep, but many children also have other infections involved.
Effects on the Brain and Behavior
06
Chronic inflammation and immune signaling can:
Alter neurotransmitter balance
Affect synaptic function and plasticity
Disrupt sensory processing and emotional regulation
Over time, this produces a child whose:
Brain wiring
Immune responses
Metabolic and neuroendocrine regulation
The outward result is a pattern of behaviors and developmental differences that we label as “autism.”
Why Symptoms Fluctuate
07
This model explains why many parents observe:
Regression after infections or immune stress
Symptom fluctuations over time
Disrupt sensory processing and emotional regulation
Partial improvements with medical or nutritional interventions
Autism, in this view, is not static, but dynamic reflecting the underlying biological state of the child.
PANDAS is the form most strongly linked to strep, but many children also have other infections involved.
What This Means for Families
08
Understanding autism as a biological, systemic condition does not replace educational or supportive therapies—but it expands the picture.
It opens the door to:
Identifying treatable biological contributors
Understanding why children differ so widely
Explaining why one-size-fits-all approaches often fail
Most importantly, it reframes autism not as a fixed label, but as a condition with mechanisms that can be studied, monitored, and—at least in part—addressed.